Prevalence of Factor Xiii Val34leu Polymorphism in Thrombosis Cases in the Southeast of Turkey and Its Correlation with Thrombosis
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چکیده
Factor XIII (Fibrin-stabilizing factor) is a tetrameric structural pro-transglutaminase from the transglutaminase family. Factor XIII activity is associated with the structure of fibrin clot. Factor XIII turns into XIII-A, which is an active transglutaminase, in the result phase of coagulation cascade together with Ca and thrombin activation. The main aim of Factor XIIIA is to connect ε(δ-glutamyl) lysyl-bound fibrin with δfibrin, α-chains and α2-plasmin inhibitor with the help of non-covalent bonds. In this way, it improves the mechanical resistance of the clot and increases its resistance against fibrinolysis. Factor XIII-A is the form of Factor XIII which carries risk in arterial or venous thromboembolisms. 5 different gene polymorphisms associated with Factor XIII-A have been defined so far. The most common one is polymorphism (FXIII-A Acta Medica Mediterranea, 2017, 33: 83
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Role of factor XIII Val34Leu polymorphism in retinal artery occlusion.
BACKGROUND AND PURPOSE Factor XIII (FXIII) Val34Leu, a common polymorphism in the gene for factor XIII, has been associated with a lower risk of stroke, myocardial infarction, and deep vein thrombosis. Ineffective fibrin cross-linking has been suggested to be causative. The aim of the present case-control study was to investigate the role of FXIII Val34Leu polymorphism in patients with retinal ...
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